Know your model.

In biomedical research, we are often trying to answer questions at different levels. By “level,” I mean from molecules, cells, tissue, organ, organ system, organism, community, and ecosystem. It is rare that biomedical research gets to the community and ecosystem level. There’s also a cost / benefit consideration to what “level” your particular research question is answering. Studying a problem at the level of the organism is much more expensive than studying a problem at the level of molecule — however one might argue that studying at the level of the organism is more biologically / clinically relevant.

cells
The cell model used in my lab, SH-SY5Y cells. Left: Non-differentiated cells, neuroblastoma, continue division. Right: Differentiated cells, stopped dividing, extended axons & dendrites, secrete neurotransmitter.

At each level, you have the thing in your lab that you are actually manipulating and observing and this thing is used to represent something greater, hopefully a more general concept. That’s known as a “model.” Continue reading